Article

Characterization of Cancer Evolution Landscape Based on Accurate Detection of Somatic Mutations in Single Tumor Cells

2023-10-09

Abstract excerpt

Accurate detection of somatic mutations in single tumor cells is greatly desired as it allows us to quantify the single-cell mutation burden and construct the mutation-based phylogenetic tree. Here we developed scNanoSeq chemistry and profiled 842 single cells from 21 human breast cancer samples. The majority of the mutation-based phylogenetic trees comprise a characteristic stem evolution followed by the clonal s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cbacb92a-d1b6-546b-a09d-bf628240eed5
DOI: 10.1101/2023.10.09.561356

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of Cancer Evolution Landscape Based on Accurate Detection of Somatic Mutations in Single Tumor CellsDOI 10.1101/2023.10.09.561356Read

Current Progresses of Single Cell DNA Sequencing in Breast Cancer ResearchSemantic proximity Read

Reconstructing mutational lineages in breast cancer by multi-patient-targeted single cell DNA sequencingSemantic proximity Read

Delineating cancer evolution with single-cell sequencing.Semantic proximity Read

Inferring active mutational processes in cancer using single cell sequencing and evolutionary constraintsSemantic proximity Read

Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing.Semantic proximity Read

Single-cell phylogenies reveal deviations from clock-like, neutral evolution in cancer and healthy tissuesSemantic proximity Read

Evolutionary signatures of human cancers revealed via genomic analysis of over 35,000 patientsSemantic proximity Read

Pan-cancer evolution signatures link clonal expansion to dynamic changes in the tumor immune microenvironment.Semantic proximity Read

Leveraging single‐cell sequencing to unravel intratumour heterogeneity and tumour evolution in human cancersSemantic proximity Read

Subclonal diversification of primary breast cancer revealed by multiregion sequencing.Semantic proximity Read

Clonal evolution in breast cancer revealed by single nucleus genome sequencing.Semantic proximity Read

Longitudinal Phylogenetic Inference of Copy Number Alterations and Single Nucleotide Variants from Single-Cell SequencingSemantic proximity Read