Subclonal diversification of primary breast cancer revealed by multiregion sequencing.

doi:10.1038/nm.3886

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Article

Subclonal diversification of primary breast cancer revealed by multiregion sequencing.

Nature medicine - 1 Jul 2015

Yates Lucy R, Gerstung Moritz, Knappskog Stian, Desmedt Christine, Gundem Gunes, Van Loo Peter, Aas Turid, Alexandrov Ludmil B, Larsimont Denis, Davies Helen, Li Yilong, Ju Young Seok, Ramakrishna Manasa, Haugland Hans Kristian, Lilleng Peer Kaare, Nik-Zainal Serena, McLaren Stuart, Butler Adam, Martin Sancha, Glodzik Dominic, Menzies Andrew, Raine Keiran, Hinton Jonathan, Jones David, Mudie Laura J, Jiang Bing, Vincent Delphine, Greene-Colozzi April, Adnet Pierre-Yves, Fatima Aquila, Maetens Marion, Ignatiadis Michail, Stratton Michael R, Sotiriou Christos, Richardson Andrea L, Lønning Per Eystein, Wedge David C, Campbell Peter J

Abstract excerpt

The sequencing of cancer genomes may enable tailoring of therapeutics to the underlying biological abnormalities driving a particular patient's tumor. However, sequencing-based strategies rely heavily on representative sampling of tumors. To understand the subclonal structure of primary breast cancer, we applied whole-genome and targeted sequencing to multiple samples from each of 50 patients' tumors (303 samples...

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Identifiers

PMID: 26099045
DOI: 10.1038/nm.3886
PMCID: PMC4500826

Genes

BRCA2
MYC
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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