Article

Single-cell phylogenies reveal deviations from clock-like, neutral evolution in cancer and healthy tissues

2022-08-11

Abstract excerpt

How tumors evolve affects cancer progression, therapy response, and relapse. However, whether tumor evolution is driven primarily by selectively advantageous or neutral mutations remains under debate. Resolving this controversy has so far been limited by the use of bulk sequencing data. Here, we leverage the high resolution of single-cell DNA sequencing (scDNA-seq) to test for clock-like, neutral evolution. Under...

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Literature Corpus work: f2080b69-1567-5b8e-a57a-41f0937899b3
DOI: 10.1101/2022.08.09.503287

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