Article

Reconstructing mutational lineages in breast cancer by multi-patient-targeted single cell DNA sequencing

2021-11-19

Abstract excerpt

Single cell DNA sequencing (scDNA-seq) methods are powerful tools for profiling mutations in cancer cells, however most genomic regions characterized in single cells are non-informative. To overcome this issue, we developed a Multi-Patient-Targeted (MPT) scDNA-seq sequencing method. MPT involves first performing bulk exome sequencing across a cohort of cancer patients to identify somatic mutations, which are then...

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Literature Corpus work: 8deac0e9-d790-5094-926c-8c7cf4cf4314
DOI: 10.1101/2021.11.16.468877

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