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Article

Pan-cancer evolution signatures link clonal expansion to dynamic changes in the tumor immune microenvironment.

Cell reports - 24 Mar 2026

Yang Xinyu, Liu Wei, Macintyre Geoff, Van Loo Peter, Markowetz Florian, Bailey Peter, Yuan Ke

Abstract excerpt

Cancer is an evolutionary process characterized by profound intratumor heterogeneity (ITH), which can be quantified using in silico estimates of cancer cell fractions (CCFs) of tumor-specific somatic mutations. We demonstrate a data-driven approach based on CCF distributions to identify 4 robust pan-cancer evolutionary signatures from 4,146 tumors across 17 cancer types in The Cancer Genome Atlas (TCGA). These...

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PMID: 41832954
DOI: 10.1016/j.celrep.2026.117098

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