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Current Progresses of Single Cell DNA Sequencing in Breast Cancer Research

1 Jan 2017

Abstract excerpt

Breast cancers display striking genetic and phenotypic diversities. To date, several hypotheses are raised to explain and understand the heterogeneity, including theories for cancer stem cell (CSC) and clonal evolution. According to the CSC theory, the most tumorigenic cells, while maintaining themselves through symmetric division, divide asymmetrically to generate non-CSCs with less tumorigenic and metastatic...

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PMID: 28924377
DOI: 10.7150/ijbs.19627

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