Article

Synthesis and biological evaluation of glutathione-responsive 2-alkoxycarbonyl allyl niclosamide prodrugs as anticancer agents

2025-08-25

Abstract excerpt

<h4>ABSTRACT</h4> Reprogrammed mitochondrial metabolism is recognized as an important target for anticancer therapy. Niclosamide, an FDA approved anthelmintic agent with mitochondrial uncoupling activity, has shown promise as an anticancer agent. However, off target mitochondrial toxicity has rendered the utility of this agent at clinically effective doses. Here, we synthesize a variety of prodrugs on the niclosa...

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Literature Corpus work: cba58d1c-f0f2-5201-91cf-3d4e939e9e63
DOI: 10.1101/2025.08.20.671294

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