Article

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

2020-04-25

Abstract excerpt

One avenue to combat multidrug-resistant Gram-negative bacteria is the co-administration of multiple drugs (combination therapy), which can be particularly promising if drugs synergize. The identification of synergistic drug combinations, however, is challenging. Detailed understanding of antibiotic mechanisms can address this issue by facilitating the rational design of improved combination therapies. Here, using...

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Literature Corpus work: 8fd1d872-9b46-5b46-b64d-07d89f0eecbb
DOI: 10.1101/2020.04.23.058875

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