Article

Niclosamide Prodrug Enhances Oral Bioavailability and Targets Vasorin-TGFβ Signaling in Hepatocellular Carcinoma

2024-10-18

Abstract excerpt

<h4>Background</h4> Hepatocellular carcinoma (HCC) ranks third in cancer-related deaths worldwide, with limited therapeutic options. While niclosamide (NIC) has shown potential for repurposing in HCC, its poor water solubility and low bioavailability limit its efficacy, and its mechanisms of action are not yet fully elucidated. <h4>Methods</h4> We designed a water-soluble NIC prodrug (NIC-PS) and evaluated its e...

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Literature Corpus work: 85bde0a7-ab55-50c6-8fa4-1dee7728e036
DOI: 10.1101/2024.10.15.618538

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