Article

A luciferase-based assay identifies niclosamide derivatives antagonizing Mcl-1 through post-translational down-regulation

2019-06-08

Abstract excerpt

The up-regulation of Mcl-1 expression is a major mechanism of cancer cell survival and therapy resistance. However, the underlying molecular mechanism remains incompletely understood, limiting the number of druggable approaches to selectively inhibit Mcl-1 function. In this study, we designed and employed a novel mechanistic high-throughput screening system to selectively uncover post-translational modulators of M...

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Literature Corpus work: 2b489dc2-cb26-50a9-a6d3-b7008b5ec35e
DOI: 10.1101/665505

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