Article

Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies

2023-08-14

Abstract excerpt

<h4>ABSTRACT</h4> Nitro fatty acids (NO 2 -FAs) are endogenously generated lipid signaling mediators from metabolic and inflammatory reactions between conjugated diene fatty acids and nitric oxide or nitrite-derived reactive species. NO 2 -FAs undergo reversible Michael addition with hyperreactive protein cysteine thiolates to induce posttranslational protein modifications that can impact protein function. Here...

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Literature Corpus work: fc888a2b-c861-5b3e-8a17-31305c2445f0
DOI: 10.1101/2023.08.11.552990

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