Article

Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity with reduced toxicity

2025-07-08

Abstract excerpt

Mitochondrial uncouplers have shown clinical potential across various diseases, including cancer. Niclosamide, an FDA-approved anthelmintic drug, acts as a mild mitochondrial uncoupler and has demonstrated anticancer activity in multiple preclinical cancer models. However, its clinical application remains limited, with some attributing this to poor bioavailability, while the underlying mechanisms are still unclear...

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Literature Corpus work: 05207c1a-6466-51b4-b61e-35a81ddecf52
DOI: 10.1101/2025.07.04.663252

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