Article

Niclosamide Prodrug Enhances Oral Bioavailability and Efficacy Against Hepatocellular Carcinoma by Targeting Vasorin-TGFβ Signaling

2025-03-05

Abstract excerpt

<h4>Background: </h4> Hepatocellular carcinoma (HCC) ranks third in cancer-related deaths worldwide, with limited therapeutic options. While niclosamide (NIC) has shown potential for repurposing in HCC, its poor water solubility and low bioavailability limit its efficacy, and its mechanisms of action are not yet fully elucidated. <h4>Methods:</h4> We designed a water-soluble NIC prodrug (NIC-PS) and evaluated its...

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Literature Corpus work: 9c19cd7a-a731-55be-855f-2e00fbf3db20
DOI: 10.22541/au.174119415.55528730/v1

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