Article

Niclosamide Prodrug Enhances Oral Bioavailability and Targets Vasorin-TGFβ Signaling in Hepatocellular Carcinoma

2024-10-25

Abstract excerpt

<h4>Background: </h4> and Purpose: Hepatocellular carcinoma (HCC) ranks third in cancer-related deaths worldwide, with limited therapeutic options. While niclosamide (NIC) has shown potential for repurposing in HCC, its poor water solubility and low bioavailability limit its efficacy, and its mechanisms of action are not yet fully elucidated. This study aimed to enhance NIC’s bioavailability by developing a water-...

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Literature Corpus work: 479b03d7-7357-5429-9a43-5d31ce9ae450
DOI: 10.22541/au.172988493.34921642/v1

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