Article

The NTR/Prodrug Revolution: Tools for Controlling Cell Loss and Regeneration

2026-04-08

Abstract excerpt

Here, we review the history, advancements, and broad utility of the NTR/prodrug system, and suggest future strategies for developing versatile ablation models. As a chemogenetic tool, the nitroreductase (NTR)/prodrug system enables precise spatiotemporal control over cell ablation. The technology leverages bacterial nitroreductase enzymes (e.g., nfsB) to convert inert prodrugs into cytotoxic agents, thereby allowi...

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Literature Corpus work: 95a33c9b-5b3e-5551-a199-1658088d5348
DOI: 10.20944/preprints202602.2055.v2

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