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Article

The cryptophycins: Their synthesis and anticancer activity

8 Feb 2002

Abstract excerpt

The cryptophycins are a unique family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. Their molecular target is tubulin protein wherein they are the most potent known stabilizers of microtubule dynamics and depolymerize microtubules at higher concentrations. They also deactivate the Bcl2 protein and produce apoptotic response much more quickly and at considerably lower...

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PMID: 11857635
DOI: 10.1002/med.10002

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