Article

In Vitro Evaluation and Mitigation of Niclosamide’s Liabilities as a COVID-19 Treatment

2022-06-24

Abstract excerpt

Niclosamide, an FDA-approved oral anthelmintic drug, has broad biological activity including anticancer, antibacterial, and antiviral properties. Niclosamide has also been identified as a potent inhibitor of SARS-CoV-2 infection in vitro , generating interest in its use for the treatment or prevention of COVID-19. Unfortunately, there are several potential issues with using niclosamide for COVID-19, including low...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d2db292-afca-5883-a1ad-109d07895ba0
DOI: 10.1101/2022.06.24.497526

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In Vitro Evaluation and Mitigation of Niclosamide’s Liabilities as a COVID-19 TreatmentDOI 10.1101/2022.06.24.497526Read

Niclosamide reverses SARS-CoV-2 control of lipophagySemantic proximity Read

Repurposing niclosamide as a novel anti-SARS-Cov-2 drug by restricting entry protein CD147Semantic proximity Read

Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the UK B.1.1.7 and SA B.1.351 variantSemantic proximity Read

<i>In Vitro</i> Activity of Cysteamine Against SARS-CoV-2 VariantsSemantic proximity Read

Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity with reduced toxicitySemantic proximity Read

Synthesis and biological evaluation of glutathione-responsive 2-alkoxycarbonyl allyl niclosamide prodrugs as anticancer agentsSemantic proximity Read

A luciferase-based assay identifies niclosamide derivatives antagonizing Mcl-1 through post-translational down-regulationSemantic proximity Read

Niclosamide potentiates TMEM16A and induces vasoconstrictionSemantic proximity Read

Niclosamide Prodrug Enhances Oral Bioavailability and Targets Vasorin-TGFβ Signaling in Hepatocellular CarcinomaSemantic proximity Read

Niclosamide Prodrug Enhances Oral Bioavailability and Targets Vasorin-TGFβ Signaling in Hepatocellular CarcinomaSemantic proximity Read

Niclosamide inhibits the replication of highly pathogenic avian influenza A (H5Nx) viruses and antiviral-resistant mutants.Semantic proximity Read

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infectionsSemantic proximity Read