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Article

Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer's disease risk.

GeroScience - 1 Feb 2023

Nazarian Alireza, Philipp Ian, Culminskaya Irina, He Liang, Kulminski Alexander M

Abstract excerpt

The mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein E (APOE) ε2 and ε4 alleles on Alzheimer's disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium (LD) patterns between 6,136 AD-affected and 10,555 AD-unaffected subjects from five independent studies to explore whether the association of the APOE ε2 allele (encoded...

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Identifiers

PMID: 35809216
DOI: 10.1007/s11357-022-00617-0
PMCID: PMC9886755

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APOE

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