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Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis.

Neurobiology of aging - 1 Nov 2022

Bracher-Smith Matthew, Leonenko Ganna, Baker Emily, Crawford Karen, Graham Andrew C, Salih Dervis A, Howell Brian W, Hardy John, Escott-Price Valentina

Abstract excerpt

The APOE-ε4 allele is known to predispose to amyloid deposition and consequently is strongly associated with Alzheimer's disease (AD) risk. There is debate as to whether the APOE gene accounts for all genetic variation of the APOE locus. Another question which remains is whether APOE-ε4 carriers have other genetic factors influencing the progression of amyloid positive individuals to AD. We conducted a...

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Identifiers

PMID: 35977442
DOI: 10.1016/j.neurobiolaging.2022.07.009
PMCID: PMC9548409

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