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Article

Genome-wide analysis identified abundant genetic modulators of contributions of the apolipoprotein E alleles to Alzheimer's disease risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2022

Nazarian Alireza, Loika Yury, He Liang, Culminskaya Irina, Kulminski Alexander M

Abstract excerpt

INTRODUCTION: The apolipoprotein E (APOE) ε2 and ε4 alleles have beneficial and adverse impacts on Alzheimer's disease (AD), respectively, with incomplete penetrance, which may be modulated by other genetic variants. METHODS: We examined whether the associations of the APOE alleles with other polymorphisms in the genome can be sensitive to AD-affection status. RESULTS: We identified associations of the ε2 and ε4...

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PMID: 34978151
DOI: 10.1002/alz.12540
PMCID: PMC9250541

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