Article

Sphingosine-1-phosphate signaling inhibition suppresses Th1-like Treg generation by reversing mitochondrial uncoupling

2024-05-21

Abstract excerpt

Inflammatory environments induce the generation of dysfunctional IFN γ + T-bet + FOXP3 + Th1-like Tregs, which show defective function and are found in autoimmune conditions including multiple sclerosis (MS). The pathways that control the generation of Th1-like Tregs are not well understood. Sphingosine-1-phosphate (S1P) signaling molecules are upregulated in Th1-like Tregs, and in vivo S1P inhibition with Fin...

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Literature Corpus work: cb8bb586-1b12-50d2-aae1-cd7113f04ecb
DOI: 10.1101/2024.05.20.594966

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