Article

Rapamycin rescues loss-of-function in blood-brain barrier-interacting regulatory T cells

2022-10-21

Abstract excerpt

In many autoimmune diseases, FOXP3 + regulatory T cells (Tregs) skew towards a pro-inflammatory and non-suppressive phenotype and are therefore unable to control the exaggerated autoimmune response. This may largely impact the success of autologous Treg therapy which is currently under investigation for treatment of autoimmune diseases, including multiple sclerosis (MS). Thus, there is a need to ensure in vivo s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 81102a93-5cab-551a-b09f-7680145286b0
DOI: 10.1101/2022.10.21.513147

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapamycin rescues loss-of-function in blood-brain barrier-interacting regulatory T cellsDOI 10.1101/2022.10.21.513147Read

Pembrolizumab Interferes with the Differentiation of Human FOXP3+–Induced T Regulatory Cells, but Not with FOXP3 Stability, through Activation of mTORSemantic proximity Read

Patients With Severe Multiple Sclerosis Exhibit Functionally Altered CD8 + Regulatory T CellsSemantic proximity Read

Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells.Semantic proximity Read

B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.Semantic proximity Read

Regulatory T cells promote myelin regeneration in the central nervous systemSemantic proximity Read

Regulatory T Cell Stability and Migration Are Dependent on mTOR.Semantic proximity Read

Abnormal effector and regulatory T cell subsets in paediatric-onset multiple sclerosisSemantic proximity Read

Hiding in Plain Sight: CD8+FOXP3+Tregs sequester CD25 and are enriched in human tissuesSemantic proximity Read

Interleukin-33 from oligodendrocytes sustains effector differentiation of tissue-resident CD8+ T cells and is a druggable target in CNS autoimmune diseaseSemantic proximity Read

Regulatory T-cells in multiple sclerosis produce IL-10 in the central 1 nervous system but are activated by Epstein-Barr VirusSemantic proximity Read

Targeted Therapy of Multiple Sclerosis: a Case for Antigen-specific TregsSemantic proximity Read

Investigating the role of inflammation-modulated microRNAs and signalling pathways in blood-barrier dysfunctionSemantic proximity Read