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Article

Sphingosine‐1‐phosphate receptor 1 signalling in T cells: trafficking and beyond

5 Mar 2014

Abstract excerpt

Sphingosine-1-phosphate (S1P) is a lipid second messenger that signals via five G protein-coupled receptors (S1P1-5 ). S1P receptor (S1PR) signalling is associated with a wide variety of physiological processes including lymphocyte biology, their recirculation and determination of T-cell phenotypes. The effect of FTY720 (Fingolimod, Gilenya™) to regulate lymphocyte egress and to ameliorate paralysis in...

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PMID: 24597601
DOI: 10.1111/imm.12272

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