Article
Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells.
PloS one - 1 Jan 2011
He Shan, Kato Koji, Jiang Jiu, Wahl Daniel R, Mineishi Shin, Fisher Erin M, Murasko Donna M, Glick Gary D, Zhang Yi
Abstract excerpt
BACKGROUND: Cellular metabolism plays a critical role in regulating T cell responses and the development of memory T cells with long-term protections. However, the metabolic phenotype of antigen-activated T cells that are responsible for the generation of long-lived memory cells has not been characterized. DESIGN AND METHODS: Using lymphocytic choriomeningitis virus (LCMV) peptide gp33-specific CD8(+) T cells...
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