Article
AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease.
EMBO reports - 1 Aug 2016
Kitz Alexandra, de Marcken Marine, Gautron Anne-Sophie, Mitrovic Mitja, Hafler David A, Dominguez-Villar Margarita
Abstract excerpt
Foxp3(+) regulatory T cells (Tregs) exhibit plasticity, which dictates their function. Secretion of the inflammatory cytokine IFNγ, together with the acquisition of a T helper 1 (Th1)-like effector phenotype as observed in cancer, infection, and autoimmune diseases, is associated with loss of Treg suppressor function through an unknown mechanism. Here, we describe the signaling events driving the generation of...
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