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Article

Regulatory T Cell Stability and Migration Are Dependent on mTOR.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2020

Vallion Romain, Divoux Jordane, Glauzy Salomé, Ronin Emilie, Lombardi Yannis, Lubrano di Ricco Martina, Grégoire Sylvie, Nemazanyy Ivan, Durand Aurélie, Fradin Delphine, Lucas Bruno, Salomon Benoit L

Abstract excerpt

CD4+ Foxp3+ regulatory T cells (Treg) are essential to maintain immune tolerance, as their loss leads to a fatal autoimmune syndrome in mice and humans. Conflicting findings have been reported concerning their metabolism. Some reports found that Treg have low mechanistic target of rapamycin (mTOR) activity and would be less dependent on this kinase compared with conventional T cells, whereas other reports suggest...

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Identifiers

PMID: 32839235
DOI: 10.4049/jimmunol.1901480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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