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Article

S1P1 deletion differentially affects TH17 and Regulatory T cells.

Scientific reports - 10 Oct 2017

Eken Ahmet, Duhen Rebekka, Singh Akhilesh K, Fry Mallory, Buckner Jane H, Kita Mariko, Bettelli Estelle, Oukka Mohamed

Abstract excerpt

Sphingosine-1 phosphate receptor 1 (S1P1) is critical for the egress of T and B cells out of lymphoid organs. Although S1P1 agonist fingolimod is currently used for the treatment of multiple sclerosis (MS) little is known how S1P1 signaling regulates Th17 and Treg cell homeostasis. To study the impact of S1P1 signaling on Th17 and Treg cell biology, we specifically deleted S1P1 in Th17 and Treg cells using IL-17A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

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Share to T-Lymphocytes, Regulatory

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Source

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Identifiers

PMID: 29018225
DOI: 10.1038/s41598-017-13376-2
PMCID: PMC5635040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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