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Article

Fingolimod attenuates splenocyte-induced demyelination in cerebellar slice cultures.

PloS one - 1 Jan 2014

Pritchard Adam J, Mir Anis K, Dev Kumlesh K

Abstract excerpt

The family of sphingosine-1-phosphate receptors (S1PRs) is G-protein-coupled, comprised of subtypes S1PR1-S1PR5 and activated by the endogenous ligand S1P. The phosphorylated version of Fingolimod (pFTY720), an oral therapy for multiple sclerosis (MS), induces S1PR1 internalisation in T cells, subsequent insensitivity to S1P gradients and sequestering of these cells within lymphoid organs, thus limiting immune...

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Identifiers

PMID: 24911000
DOI: 10.1371/journal.pone.0099444
PMCID: PMC4049809

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MOG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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