Article
IL-1β induced HIF-1α inhibits the differentiation of human FOXP3+ T cells.
Scientific reports - 28 Mar 2017
Feldhoff Lea M, Rueda Cesar M, Moreno-Fernandez Maria E, Sauer Johanna, Jackson Courtney M, Chougnet Claire A, Rupp Jan
Abstract excerpt
Differentiation of regulatory Treg (Treg) in the periphery is critical to control inflammatory processes. Although polarization of inducible Treg (iTreg) often occurs in an inflammatory environment, the effects exerted by inflammation on human iTreg differentiation have not been extensively studied. We observed that IL-1β significantly reduced the frequency of FOXP3+ T cells under iTreg-polarizing conditions....
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