Article

Opioid withdrawal engages a habenular subpopulation responsive to aversive states

2026-04-30

Abstract excerpt

<h4> A bstract </h4> Opioid withdrawal produces a protracted aversive state that is a driving factor towards relapse for patients with opioid use disorder. The habenula is known to mediate symptoms of withdrawal across several substance use disorders, including alcohol, nicotine, and opioid use disorder. However, it is unclear which habenular populations contribute to withdrawal symptoms. Here, we identify a ce...

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Literature Corpus work: 81e4e5ab-d9e1-5b9c-beae-76f835705354
DOI: 10.64898/2026.04.29.721196

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