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Article

Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT2 Deficits.

Sleep - 1 Dec 2016

Grønli Janne, Clegern William C, Schmidt Michelle A, Nemri Rahmi S, Rempe Michael J, Gallitano Amelia L, Wisor Jonathan P

Abstract excerpt

STUDY OBJECTIVE: The expression of the immediate early gene early growth response 3 (Egr3) is a functional marker of brain activity including responses to novelty, sustained wakefulness, and sleep. We examined the role of this gene in regulating wakefulness and sleep. METHODS: Electroencephalogram/electromyogram (EEG/EMG) were recorded in Egr3-/- and wild-type (WT) mice during 24 h baseline, 6 h sleep disruption...

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Identifiers

PMID: 28057087
DOI: 10.5665/sleep.6324
PMCID: PMC5103807

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