Glutamatergic neurons in the preoptic hypothalamus promote wakefulness, destabilize NREM sleep, suppress REM sleep, and regulate cortical dynamics

Abstract excerpt

<h4>ABSTRACT</h4> Clinical and experimental data from the last nine decades indicate that the preoptic area of the hypothalamus is a critical node in a brain network that controls sleep onset and homeostasis. By contrast, we recently reported that a group of glutamatergic neurons in the lateral and medial preoptic area increases wakefulness, challenging the long-standing notion in sleep neurobiology that the preo...

Topics

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• Attention
• Emotions
• Memory
• Neural Pathways
• Sleep
• Sleep, REM
• Sleep Wake Disorders
• Wakefulness

Identifiers and source

Literature Corpus work

65fd3e76-576a-5f01-9c75-7efa2f5e3e1b

DOI

10.1101/2020.10.20.347260