Article

Spatiotemporal remodeling in the habenula marks the onset of depression

2025-11-19

Abstract excerpt

<title>Abstract</title> <p>Chronic stress has lasting adverse consequences that can lead, over time, to depressive disorders1‑4 yet identifying the optimal timeframe for effective therapies remains an unmet challenge. Enhanced neuronal activity and disrupted aversion-encoding in lateral habenula (LHb) are important mediators of stress-related behavioral repercussions5‑10, although the precise timing of its contri...

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Literature Corpus work: 3c869ccd-a563-54c2-8791-80420cda00bb
DOI: 10.21203/rs.3.rs-7773881/v1

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