Article

Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interference

2021-02-17

Abstract excerpt

Glioblastomas are highly malignant tumors of the central nervous system. Evidence suggests that these tumors display large intra- and inter-patient heterogeneity hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies 1–3 . However, the source for dynamic reorganization of cellular states within their spatial context remains elusive. Here, we in-depth characterized glioblastomas by...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8490e6c4-3ba5-50d0-8b09-f15785aa1d3c
DOI: 10.1101/2021.02.16.431475

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interferenceDOI 10.1101/2021.02.16.431475Read

Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interferenceSemantic proximity Read

Spatially Integrated Multi-Omics reveals the Multicellular Landscape of Progenitor-Driven Glioblastoma ProgressionSemantic proximity Read

Histologically defined intratumoral sequencing uncovers evolutionary cues into conserved molecular events driving gliomagenesisSemantic proximity Read

Spatial Single Cell Lipid-Transcriptomic Coupling Reveals Metabolic Niches in GlioblastomaSemantic proximity Read

Genetic evolution and cellular interactions within the tumour microenvironment determine glioblastoma progressionSemantic proximity Read

Transcriptome analysis reveals tumor microenvironment changes in glioblastomaSemantic proximity Read

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneitySemantic proximity Read

Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptationsSemantic proximity Read

The multilayered transcriptional architecture of glioblastoma ecosystemsSemantic proximity Read

Molecular and cellular intratumoral heterogeneity in primary glioblastoma: clinical and translational implicationsSemantic proximity Read

Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell ResolutionSemantic proximity Read

Molecular diversity in isocitrate dehydrogenase-wild-type glioblastomaSemantic proximity Read