Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity.

doi:10.1073/pnas.2210991120

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity.

Proceedings of the National Academy of Sciences of the United States of America - 16 May 2023

Raviram Ramya, Raman Anugraha, Preissl Sebastian, Ning Jiangfang, Wu Shaoping, Koga Tomoyuki, Zhang Kai, Brennan Cameron W, Zhu Chenxu, Luebeck Jens, Van Deynze Kinsey, Han Jee Yun, Hou Xiaomeng, Ye Zhen, Mischel Anna K, Li Yang Eric, Fang Rongxin, Baback Tomas, Mugford Joshua, Han Claudia Z, Glass Christopher K, Barr Cathy L, Mischel Paul S, Bafna Vineet, Escoubet Laure, Ren Bing, Chen Clark C

Abstract excerpt

In 2021, the World Health Organization reclassified glioblastoma, the most common form of adult brain cancer, into isocitrate dehydrogenase (IDH)-wild-type glioblastomas and grade IV IDH mutant (G4 IDHm) astrocytomas. For both tumor types, intratumoral heterogeneity is a key contributor to therapeutic failure. To better define this heterogeneity, genome-wide chromatin accessibility and transcription profiles of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Neoplasms

Share to Chromatin

Share to Glioblastoma

Share to Glioma Diagnosis and Treatment

Share to Isocitrate Dehydrogenase

Share to Mutation

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 37155843
DOI: 10.1073/pnas.2210991120
PMCID: PMC10194019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity.PMID 37155843Read ↗

Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell ResolutionSemantic proximity Read ↗

Acquired genetic and cell-state changes in IDH-mutant glioma progression.Semantic proximity Read ↗

The multilayered transcriptional architecture of glioblastoma ecosystemsSemantic proximity Read ↗

Genetic evolution and cellular interactions within the tumour microenvironment determine glioblastoma progressionSemantic proximity Read ↗

Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress responseSemantic proximity Read ↗

Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma.Semantic proximity Read ↗

Molecular diversity in isocitrate dehydrogenase-wild-type glioblastomaSemantic proximity Read ↗

Multi◻region whole◻genome and transcriptomic profiling uncovers plastic, subclone◻linked cell states in high◻grade diffuse astrocytomasSemantic proximity Read ↗

Multiregional Sequencing of IDH-WT Glioblastoma Reveals High Genetic Heterogeneity and a Dynamic Evolutionary HistorySemantic proximity Read ↗

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.Semantic proximity Read ↗

Harmonized single-cell landscape, intercellular crosstalk and tumor architecture of glioblastomaSemantic proximity Read ↗

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell MultiomicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.