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<i>OPRM1</i> A118G and serum β-endorphin interact with sex and digit ratio (2D:4D) to influence risk and course of alcohol dependence

2017-10-09

Abstract excerpt

Activation of mesolimbic mu-opioid receptor by its endogenous ligand, β-endorphin, mediates part of the rewarding effects of alcohol, yet there is controversial evidence surrounding the relationship between the functional mu-opioid receptor gene ( OPRM1 ) A118G single nucleotide polymorphism and alcohol dependence risk. Some preclinical evidence suggests that sex and sex hormone-dependent prenatal brain organizat...

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Literature Corpus work
cb3923b4-ed83-525f-a571-e644cc5ac806
DOI
10.1101/200196
Open publication

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