Article
Oprm1 A112G, a single nucleotide polymorphism, alters expression of stress-responsive genes in multiple brain regions in male and female mice.
Psychopharmacology - 1 Sept 2018
Collins Devon, Randesi Matthew, da Rosa Joel Correa, Zhang Yong, Kreek Mary Jeanne
Abstract excerpt
BACKGROUND: OPRM1 A118G, a functional human mu-opioid receptor (MOR) polymorphism, is associated with drug dependence and altered stress responsivity in humans as well as altered MOR signaling. MOR signaling can regulate many cellular processes, including gene expression, and many of the long-term, stable effects of drugs and stress may stem from changes in gene expression in diverse brain regions. A mouse model...
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