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Article

Dual growth of adolescent smoking and drinking: evidence for an interaction between the mu-opioid receptor (OPRM1) A118G polymorphism and sex.

Addiction biology - 1 Nov 2013

Kleinjan Marloes, Poelen Evelien A, Engels Rutger C M E, Verhagen Maaike

Abstract excerpt

Smoking and alcohol use often co-occur during adolescence, but little is known about the codevelopment of these substances. In the search for etiological factors that help to explain the development of adolescent substance use patterns, studies have revealed substantial heritability for both alco...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22260295
DOI: 10.1111/j.1369-1600.2011.00422.x

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22260295-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Research trail→

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Dual growth of adolescent smoking and drinking: evidence for an interaction between the mu-opioid receptor (OPRM1) A118G polymorphism and sex.PMID 22260295Read ↗

Initial evidence of an association between OPRM1 and adolescent alcohol misuse.Semantic proximity Read ↗

Co-development of early adolescent alcohol use and depressive feelings: The role of the mu-opioid receptor A118G polymorphism.Semantic proximity Read ↗

<i>OPRM1</i> A118G and serum β-endorphin interact with sex and digit ratio (2D:4D) to influence risk and course of alcohol dependenceSemantic proximity Read ↗

Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: the example of alcohol use promoting peers and μ-opioid receptor M1 variation.Semantic proximity Read ↗

Adolescent Substance Abuse, Transgenerational Consequences and EpigeneticsSemantic proximity Read ↗

A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology.Semantic proximity Read ↗

A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation.Semantic proximity Read ↗

Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents.Semantic proximity Read ↗

Effects of the serotonin transporter (5-HTTLPR) and α2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study.Semantic proximity Read ↗

Influence of the A118G Polymorphism of the OPRM1 Gene and Exon 3 VNTR Polymorphism of the DRD4 Gene on Cigarette Craving After Alcohol Administration.Semantic proximity Read ↗

Neurobiological contributions to addiction: a narrative review of adolescent and adult vulnerabilities.Semantic proximity Read ↗

The μ-opioid receptor gene and smoking initiation and nicotine dependenceSemantic proximity Read ↗

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