Article

Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome (AGS)-ortholog mutants of <i>Saccharomyces cerevisiae</i>

2023-10-02

Abstract excerpt

<h4>SUMMARY</h4> Ribonucleoside monophosphates (rNMPs) are abundantly found within genomic DNA of cells. The embedded rNMPs alter DNA properties and impact genome stability. Mutations in ribonuclease (RNase) H2, a key enzyme for rNMP removal, are associated with the Aicardi-Goutières syndrome (AGS), a severe neurological disorder. Here, we engineered two AGS-ortholog mutations in Saccharomyces cerevisiae : rnh2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb2b6ba4-9e86-5098-9a11-1774ac9aa956
DOI: 10.1101/2023.10.02.560505

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome (AGS)-ortholog mutants of <i>Saccharomyces cerevisiae</i>DOI 10.1101/2023.10.02.560505Read

Human <i>ribomes</i> reveal DNA-embedded ribonucleotides as a new type of epigenetic markSemantic proximity Read

RNase H2 roles in genome integrity revealed by unlinking its activities.Semantic proximity Read

rNMPID: a database for riboNucleoside Mono-Phosphates In DNASemantic proximity Read

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflictsSemantic proximity Read

Metabolism of epigenetic ribonucleosides leads to nucleolar stress and cytotoxicitySemantic proximity Read

Detection and mutational consequences of embedded ribonucleotidesSemantic proximity Read

Improved short nascent strand sequencing (iSNS-seq) enhances DNA replication origin detection and reduces non-origin biasesSemantic proximity Read

snoRNA-guided tRNA 2’-O-methylation controls codon-biased gene expression and cellular statesSemantic proximity Read

Genetic requirements for repair of lesions caused by single genomic ribonucleotides in S phaseSemantic proximity Read

Frequency and patterns of ribonucleotide incorporation around autonomously replicating sequences in yeast reveal the division of labor of replicative DNA polymerases.Semantic proximity Read

Genome instability due to ribonucleotide incorporation into DNA.Semantic proximity Read

Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex.Semantic proximity Read