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Article

Genome instability due to ribonucleotide incorporation into DNA.

Nature chemical biology - 1 Oct 2010

Nick McElhinny Stephanie A, Kumar Dinesh, Clark Alan B, Watt Danielle L, Watts Brian E, Lundström Else-Britt, Johansson Erik, Chabes Andrei, Kunkel Thomas A

Abstract excerpt

Maintaining the chemical identity of DNA depends on ribonucleotide exclusion by DNA polymerases. However, ribonucleotide exclusion during DNA synthesis in vitro is imperfect. To determine whether ribonucleotides are incorporated during DNA replication in vivo, we substituted leucine or glycine for an active-site methionine in yeast DNA polymerase ϵ (Pol ϵ). Ribonucleotide incorporation in vitro was three-fold...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20729855
DOI: 10.1038/nchembio.424
PMCID: PMC2942972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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