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Article

Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex.

Nucleic acids research - 1 Jan 2009

Chon Hyongi, Vassilev Alex, DePamphilis Melvin L, Zhao Yingming, Zhang Junmei, Burgers Peter M, Crouch Robert J, Cerritelli Susana M

Abstract excerpt

Eukaryotic RNase H2 is a heterotrimeric enzyme. Here, we show that the biochemical composition and stoichiometry of the human RNase H2 complex is consistent with the properties previously deduced from genetic studies. The catalytic subunit of eukaryotic RNase H2, RNASEH2A, is well conserved and similar to the monomeric prokaryotic RNase HII. In contrast, the RNASEH2B and RNASEH2C subunits from human and...

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PMID: 19015152
DOI: 10.1093/nar/gkn913
PMCID: PMC2615623

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