Article

Genetic requirements for repair of lesions caused by single genomic ribonucleotides in S phase

2022-07-02

Abstract excerpt

Single ribonucleoside monophosphates (rNMPs) are transiently present in eukaryotic genomes. The RNase H2-dependent ribonucleotide excision repair (RER) pathway ensures error-free genomic rNMP removal. In pathological conditions, genomic rNMP levels can rise and persist. If these rNMPs hydrolyse in, or prior to, S phase, toxic single-ended double-strand breaks (seDSBs) can occur upon an encounter with replication f...

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Literature Corpus work: 43ef002d-8ce7-52d8-9629-d565b7c09cd2
DOI: 10.1101/2022.06.30.498227

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