Article
Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.
Nature communications - 20 Oct 2017
Karpel-Massler Georg, Ishida Chiaki Tsuge, Bianchetti Elena, Zhang Yiru, Shu Chang, Tsujiuchi Takashi, Banu Matei A, Garcia Franklin, Roth Kevin A, Bruce Jeffrey N, Canoll Peter, Siegelin Markus D
Abstract excerpt
Certain gliomas often harbor a mutation in the activity center of IDH1 (R132H), which leads to the production of the oncometabolite 2-R-2-hydroxyglutarate (2-HG). In six model systems, including patient-derived stem cell-like glioblastoma cultures, inhibition of Bcl-xL induces significantly more apoptosis in IDH1-mutated cells than in wild-type IDH1 cells. Anaplastic astrocytoma samples with mutated IDH1 display...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.