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Article

Cassane diterpenoid derivative induces apoptosis in IDH1 mutant glioma cells through the inhibition of glutaminase in vitro and in vivo.

Phytomedicine : international journal of phytotherapy and phytopharmacology - 1 Feb 2021

Huang Guo-Dong, Chen Fan-Fan, Ma Guo-Xu, Li Wei-Ping, Zheng Yue-Yang, Meng Xiang-Bao, Li Zong-Yang, Chen Lei

Abstract excerpt

BACKGROUND: Glioblastoma multiforme (GBM) is the most frequent, lethal and aggressive tumour of the central nervous system in adults. The discovery of novel anti-GBM agents based on the isocitrate dehydrogenase (IDH) mutant phenotypes and classifications have attracted comprehensive attention. PURPOSE: Diterpenoids are a class of naturally occurring 20-carbon isoprenoid compounds, and have previously been shown...

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Identifiers

PMID: 33529962
DOI: 10.1016/j.phymed.2020.153434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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