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Article

Acid Ceramidase: A Novel Therapeutic Target in Cancer

4 Mar 2019

Abstract excerpt

Sphingolipids are important constituents of the eukaryotic cell membrane which govern various signaling pathways related to different aspects of cell survival. Ceramide and Sphingosine are interconvertible sphingolipid metabolites, out of which Ceramide is pro-apoptotic and sphingosine is anti-apoptotic in nature. The conversion of ceramide to sphingosine is mediated by Acid Ceramidase (ASAH1) thus maintaining a...

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PMID: 30827244
DOI: 10.2174/1568026619666190227222930

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