The co-evolution of the genome and epigenome in colorectal cancer.

doi:10.1038/s41586-022-05202-1

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Article

The co-evolution of the genome and epigenome in colorectal cancer.

Nature - 1 Nov 2022

Heide Timon, Househam Jacob, Cresswell George D, Spiteri Inmaculada, Lynn Claire, Mossner Maximilian, Kimberley Chris, Fernandez-Mateos Javier, Chen Bingjie, Zapata Luis, James Chela, Barozzi Iros, Chkhaidze Ketevan, Nichol Daniel, Gunasri Vinaya, Berner Alison, Schmidt Melissa, Lakatos Eszter, Baker Ann-Marie, Costa Helena, Mitchinson Miriam, Piazza Rocco, Jansen Marnix, Caravagna Giulio, Ramazzotti Daniele, Shibata Darryl, Bridgewater John, Rodriguez-Justo Manuel, Magnani Luca, Graham Trevor A, Sottoriva Andrea

Abstract excerpt

Colorectal malignancies are a leading cause of cancer-related death1and have undergone extensive genomic study2,3. However, DNA mutations alone do not fully explain malignant transformation4-7. Here we investigate the co-evolution of the genome and epigenome of colorectal tumours at single-clone resolution using spatial multi-omic profiling of individual glands. We collected 1,370 samples from 30 primary cancers...

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Identifiers

PMID: 36289335
DOI: 10.1038/s41586-022-05202-1
PMCID: PMC9684080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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