Article

Dissection and reconstruction of the colorectal cancer tumor microenvironment

2023-11-04

Abstract excerpt

Patient-derived organoids (PDOs) are the reference in vitro human disease models. However, the utility of colorectal cancer (CRC) PDOs is hindered by the lack of a tumor microenvironment (TME). To address this limitation, we built a living biobank of CRC PDOs with autologous stromal and immune TME. We characterized the original tumors and traditional monocultures using single-cell RNA-seq (scRNA-seq) and whole ex...

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Literature Corpus work: 8a00d78e-8960-532e-8a35-19c28dbbd854
DOI: 10.1101/2023.11.01.565169

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