Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors.

doi:10.1016/j.cell.2023.11.006

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Article

Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors.

Cell - 7 Dec 2023

Heiser Cody N, Simmons Alan J, Revetta Frank, McKinley Eliot T, Ramirez-Solano Marisol A, Wang Jiawei, Kaur Harsimran, Shao Justin, Ayers Gregory D, Wang Yu, Glass Sarah E, Tasneem Naila, Chen Zhengyi, Qin Yan, Kim William, Rolong Andrea, Chen Bob, Vega Paige N, Drewes Julia L, Markham Nicholas O, Saleh Nabil, Nikolos Fotis, Vandekar Simon, Jones Angela L, Washington M Kay, Roland Joseph T, Chan Keith S, Schürpf Thomas, Sears Cynthia L, Liu Qi, Shrubsole Martha J, Coffey Robert J, Lau Ken S

Abstract excerpt

Colorectal cancer exhibits dynamic cellular and genetic heterogeneity during progression from precursor lesions toward malignancy. Analysis of spatial multi-omic data from 31 human colorectal specimens enabled phylogeographic mapping of tumor evolution that revealed individualized progression trajectories and accompanying microenvironmental and clonal alterations. Phylogeographic mapping ordered genetic events,...

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Identifiers

PMID: 38065082
DOI: 10.1016/j.cell.2023.11.006
PMCID: PMC10756562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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