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Article

Genetic and biological hallmarks of colorectal cancer.

Genes & development - 1 Jun 2021

Li Jiexi, Ma Xingdi, Chakravarti Deepavali, Shalapour Shabnam, DePinho Ronald A

Abstract excerpt

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to understand how genetic alterations in colorectal cancer drive cancer cell biology properties and shape the heterotypic...

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Identifiers

PMID: 34074695
DOI: 10.1101/gad.348226.120
PMCID: PMC8168558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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