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Single-cell integration analysis reveals molecular signatures of the tumor microenvironment in early-onset colorectal cancer

18 Nov 2025

Abstract excerpt

The incidence of early-onset colorectal cancer (CRC), defined as cases diagnosed in individuals under 50, is rising globally. However, its molecular and immune characteristics remain poorly understood. In this study, we analyze single-cell RNA sequencing data from 168 CRC patients, aged 22 to 91, to investigate differences between early-onset and standard-onset CRC. We find a reduced proportion of...

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PMID: 41254101
DOI: 10.1038/s41698-025-01129-8

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